ScitoVation Nabs Leslie Recio, PhD DABT, as Chief Scientific Officer

Amanda Holdan News, Press Release

DURHAM, N.C. (PRWEB) APRIL 28, 2022 ScitoVation is pleased to announce Leslie Recio, PhD, DABT, as the new Chief Scientific Officer. Dr. Recio was the Chief Scientific Officer and Director of the Genetic and Molecular Toxicology group at ILS. Dr. Recio will help lead the team of Senior Scientists, drive priorities in New Approach Methods and help secure new business ventures. …

Blue circles celebratory background

ScitoVation Senior Research Fellow receives 2022 Arnold J. Lehman Award from the Society of Toxicology.

Amanda Holdan Blog

Posted by Dr. Mel Andersen, Senior Research Fellow, ScitoVation.    ScitoVation is pleased to announce that Senior Research Fellow, Dr. Jeffrey W. Fisher (Jeff) is the recipient of the 2022 Arnold J. Lehman Award from the Society of Toxicology (SOT). SOT is a professional and scholarly organization of scientists from academic institutions, government, and industry with membership from both the …

Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling in Nanomedicine, Food Safety and Human Health Risk Assessment and Roles of Artificial Intelligence (AI) Approaches in these Areas

ScitoVation News, Webinars

In this presentation, Dr. Zhoumeng Lin introduces how we develop physiologically based pharmacokinetic (PBPK) models of drugs, environmental chemicals and nanoparticles for applications in nanomedicine, food safety, and human health risk assessments. He presents his recent studies to illustrate each application. Dr. Zhoumeng Linalso introduces a new physiological parameter database for PBPK modeling in food-producing animals, including cattle, swine, sheep, …

Chemical structure-property relationships and PBPK modeling: Progress and Perspectives

Amanda Holdan News, Webinars

Dr. Kannan Krishna, Chief of the Air and Site Assessment and Climate indicators Branch (ASACIB) at the Office of Environmental Health Hazard Assessment (OEHHA) of California Environmental Protection Agency, will reflect the ground-breaking work over the past 30 years in the area of chemical structure property relationships and PBPK modeling and the current thinking about way forward. What you’ll learn:  …

Clinical Pharmacology During Pregnancy Book Cover

Upcoming Book Release: Clinical Pharmacology during Pregnancy, second edition, September 24, 2021 

ScitoVation Blog

by Jeff Fisher   Edited by  Donald Mattison   Lee-Ann Halbert  I was the senior author of one chapter in the newly released textbook, “Clinical Pharmacology During Pregnancy, second edition.”  Coauthors on the original research publications include scientists from the US FDA, Duke University, and Proctor & Gamble Corporation.  The editors were Dr Donald Mattison and Ms. Lee-Ann Halbert.  Dr Mattison, a physician/researcher has been a strong advocate of computational methods in the field of toxicology throughout his distinguished career with a focus …

brown beverage

New publication investigating mode of action for high-dose effects of 4-methylimidazole

Patrick McMullen Blog

by Patrick McMullen We are pleased to announce our most recent manuscript, A systematic approach to evaluate plausible modes of actions for mouse lung tumors in mice exposed to 4-methylimidazole, published in Regulatory Toxicology and Pharmacology. 4-methylimidazole is a ubiquitous compound present in foods that undergo thermal browning (i.e., Maillard reaction) processes. The work described here—a combined effort of investigators from ScitoVation and ToxStrategies supported by the American Beverage Association—aimed …

A graph showing value of KMD

The Importance of using Kinetically Derived Maximum Dose (KMD)

ScitoVation Blog

KMD allows for design of in-life experiments that are not confounded by non-linear effects, including saturation of absorption processes. This results in a data package that is more easily interpreted because of its increased relevance to human exposures.  by Jeff Fisher For those who design repeated dose, subchronic and chronic animal toxicity studies, this concept may be an additional responsibility for you.  Gone are the …

Damaged DNA

Discovery of a new mechanism for genetic change: Exitron splicing implications for carcinogenesis

ScitoVation Blog

by Michael Black Carcinogenesis, or the process of transformation of cells to a cancerous state, often is associated with aberrations in messenger RNA splicing. Removal of introns in pre-mRNA is an essential step in normal cell processing of mRNA prior to transcription of a peptide from a final mRNA transcript. Alternative splicing of pre-mRNA gives cells the ability to regulate multiple final mRNA products from a single gene, adding diversity to the population …

3D heart

New Approach Methodologies for Environmental Cardiotoxicity Testing

ScitoVation Blog

by Marjory Moreau Recently I attended  a webinar on “Cardiac toxicity Evaluation with a human tissue-engineered model” by Kareen Coulombe, professor at Brown University. I am still blown away every time I hear Dr. Coulombe speak on this subject. In addition to being an excellent speaker, the work she and her team are doing is incredible. I recently wrote a blog on the brain and all its complexity because the brain is not an organ I had worked …