Towards Translating In Vitro Measures Of Thyroid Hormone System Disruption To In Vivo Responses In The Pregnant Rat Via A Biologically Based Dose Response (BBDR) Model

Amanda Holdan News, Webinars

We are excited to present our first recorded installment for our 2024 webinar series. Jeff Fisher, PhD, ScitoVation’s Senior Science Fellow, will be speaking about thyroid disruption and IVIVE based on his latest publication.  ScitoVation scientists continue advancing the benefits of IVIVE modeling.  What you’ll learn:  Thyroid modeling demonstrating IVIVE for a molecular initiating event determined in vitro How to …

Towards translating in vitro measures of thyroid hormone system disruption to in vivo responses in the pregnant rat via a biologically based dose response (BBDR) model

Amanda Holdan News, Publication

Jeffrey Fisher (a,*), Conrad Housand (b) David Mattie (c), Andy Nong (a), Marjory Moreau (a), Mary Gilbert (d) (a) ScitoVation, LLC, Research Triangle Park, NC 27713, USA (b) Magnolia Sciences, Winter Springs, FL, United States of America (c) AFRL/711 HPW/RHBAF, WPAFB, OH, United States of America (d) Office of Research and Development, Center for Public Health and Environmental Assessment, US …

Graphic from Moreau et al.

Animal-free assessment of developmental toxicity: Combining PBPK modeling with the ReproTracker assay

Amanda Holdan News, Publication

Marjory Moreau (a,*,1), Amer Jamalpoor (b,1,) John Carter Hall (a), Jeffrey Fisher (a), Sabine Hartvelt (b), Giel Hendriks (b), Andy Nong (a), Todor Antonijevic (a) (a) ScitoVation, LLC, Research Triangle Park, NC 27713, USA (b) Toxys, Leiden Bioscience Park, Oegstgeest, the Netherlands   Abstract: in vitro screening platforms to assess teratogenic potential of compounds are emerging rapidly. ReproTracker is a …

Generic PK models for Mother-to-Offspring Transfer

Generic Pharmacokinetic Models for Mother-to-Offspring Transfer of Chemicals

Amanda Holdan News, Webinars

Our speaker is Dustin Kapraun, PhD, physical scientist with the Center for Public Health and Environmental Assessment (CPHEA) in the Office of Research and Development (ORD) at the U.S. Environmental Protection Agency (EPA). In developing human health risk assessments, it is important to consider pregnant women, developing fetuses, and nursing children because chemical exposures experienced by these groups can lead …

Stever Johnson AI

ToxAIcology – the future of toxicology is AI

Amanda Holdan News, Webinars

Artificial Intelligence (AI) is impacting all types of work, including toxicology. Dr Hartung will discuss how to move toxicology to a more holistic and integrated paradigm using AI and how AI plays a role in setting the direction of “Toxicology for the 21st Century 2.0” in future decades.   What you’ll learn:  Sources of Big Data for toxicology and various AI …

Physiologically based pharmacokinetic modeling as a data analysis and study design tool – case studies in nonlinear pharmacokinetics

Amanda Holdan News, Webinars

We just had a wonderful talk from Dr. Dan Hoer. Dr Hoer is a physical scientist with the US Environmental Protection Agency, Office of Pesticide Programs. His talk will focus on non-linear PBPK modeling, and the advantages offered by this approach.  What you’ll learn:  Important advantages of PBPK modeling over statistical methods that are often restricted to bimodal distinctions of …