Dosimetry (PBPK)
PBPK Modeling and Human-Relevant Dose Translation
External dose does not always tell you what matters. PBPK modeling and qIVIVE help translate exposure into biologically relevant internal dose.
ScitoVation uses PBPK modeling, IVIVE/qIVIVE, reverse dosimetry, route-to-route extrapolation, and life-stage modeling to help clients understand how chemicals and drugs behave across species, routes, exposure scenarios, and human populations.
Through optimized ScitoSim-powered workflows, these established methods can be delivered with improved consistency, documentation, and reporting efficiency.
What we help you answer
- What human exposure level corresponds to an in vitro point of departure?
- How do animal findings translate to humans?
- Are children, pregnant women, lactating individuals, or other life stages expected to have different internal exposures?
- Can biomonitoring data be translated into estimated external exposure?
- Which assumptions or parameters drive the conclusion?
- How should uncertainty be communicated to regulators and stakeholders?
Services
- PBPK model development and application
- IVIVE and qIVIVE
- Human-equivalent dose estimation
- Reverse dosimetry
- Route-to-route extrapolation
- Species extrapolation
- Life-stage modeling
- Sensitivity analysis
- Model documentation and regulatory-facing reports
For PBPK modelers
Sophisticated users can explore ScitoSim platform access for pre-populated data, literature-assisted parameter extraction, sensitivity analysis, audit trails, and time savings. ScitoVation's toxicologists are available to review model qualification and assumptions where needed.