Integrated Safety Assessments

Integrated Safety Assessments Powered by Expert Workflows

The strongest toxicology decisions rarely come from one data stream. They come from integrating evidence.

ScitoVation combines literature synthesis, transcriptomics, PBPK/qIVIVE, biological similarity, exposure interpretation, uncertainty analysis, and expert toxicology judgment into unified safety assessments.

Best for

• Regulatory submissions and agency engagement
• Product stewardship decisions
• Chemical class evaluations
• Litigation support
• Consortium positions
• Substitution assessments
• Data-poor compounds
• Drug impurity assessments
• Emerging risk evaluations

Integrated workflow

1. Evidence landscape: what is known from the literature and regulatory record?
2. Mechanistic evidence: what do transcriptomics and related methods suggest about bioactivity, biomarkers, and mode of action?
3. Human relevance: how do in vitro or animal findings translate to human exposure?
4. Uncertainty analysis: what questions remain, and which uncertainties matter most?
5. Structured conclusion: what scientific position can be supported, and what additional work would strengthen it?

Integral Consulting partnership

When appropriate, ScitoVation can draw on its strategic alliance with Integral Consulting for expanded support in exposure science, toxicology, epidemiology, data management, DABT review, regulatory submission support, and agency-response strategy.