Applications
Turn Complex Toxicology Questions Into Clearer Safety DecisionsScitoVation combines scientific consulting with computational toxicology, transcriptomics, PBPK/qIVIVE, and New Approach Methodologies (NAMs) to help teams answer specific safety and regulatory questions.
Start with the decision you need to make. Whether you are translating an experimental finding to human exposure, interpreting a biological response, or prioritizing compounds within a tiered safety strategy, we help connect the evidence to the next step.
Explore Our Applications
Application | What It Helps You Answer | How ScitoVation Helps |
|---|---|---|
What human dose or exposure corresponds to an experimental finding? How might exposure differ across routes, species, life stages, or susceptible populations? | Apply PBPK modeling, qIVIVE, reverse dosimetry, and exposure analysis to translate experimental findings into human-relevant dose and exposure estimates. | |
Transcriptomics: Point of Departure, Mode of Action, and Similarity | At what dose does biological activity begin? What pathways or mechanisms are involved? Do compounds behave similarly enough to support grouping or read-across? | Use transcriptomics, benchmark-dose modeling, pathway interpretation, and biological similarity analysis to turn gene-expression responses into decision-relevant evidence. |
Which compounds need attention first? What evidence is sufficient for the decision? Where would additional testing add the most value? | Build tiered, decision-led NAMs strategies integrating computational screening, in vitro and transcriptomic evidence, dosimetry, and exposure assessment. |
Not Sure Which Application Fits Your Question?
You do not need to select a method before speaking with us. Bring us the compound, finding, exposure question, or regulatory challenge, and our scientists can help determine which evidence and analyses are most appropriate for you.