brown beverage

by Patrick McMullen We are pleased to announce our most recent manuscript, A systematic approach to evaluate plausible modes of actions for mouse lung tumors in mice exposed to 4-methylimidazole, published… Read more »

A graph showing value of KMD

KMD allows for design of in-life experiments that are not confounded by non-linear effects, including saturation of absorption processes. This results in a data package that is more easily interpreted… Read more »

Damaged DNA

by Michael Black Carcinogenesis, or the process of transformation of cells to a cancerous state, often is associated with aberrations in messenger RNA splicing. Removal of introns in pre-mRNA is an essential step in normal cell… Read more »

3D heart

by Marjory Moreau Recently I attended  a webinar on “Cardiac toxicity Evaluation with a human tissue-engineered model” by Kareen Coulombe, professor at Brown University. I am still blown away every time I hear Dr. Coulombe… Read more »

Descriptive words blog

by Dr. Jean Orelien Last year, the US EPA declared they would phase away from animal testing by 2035. Reaching this milestone will require the maturity of the risk assessment… Read more »

representing 3D liver models

by Aarati Ranade Every time we perform an experiment with hepatocytes, I am curious to see how the culture looks over time after plating the cells. I carefully place the cell culture plate under the microscope.… Read more »

Alternatives to Animal Testing

by Alina Y. Efremenko One of my memorable moments when I was a teenager was my family’s trip to the Grand Canyon. That was my first experience riding a horse.… Read more »

by Gustavo Nativio Hey there! I‘m the resident intern here at ScitoVation for the summer. As someone deeply interested in systems biology and solving biological problems using mathematics and computational models, the work done by ScitoVation is fascinating to me. ScitoVation is using… Read more »

by Raymond Samuel What is High Content Imaging?  High content imaging, or HCI, is microscopy that is efficient, objective, and quantitative.  It is the combination of technologies that allows efficient, objective acquisition of images, automated identification of… Read more »

by Marjory Moreau, Ph.D. I have worked in PBPK modeling for many years and until a few months ago, I never had to deal with the brain compartment. Well, I had a brain compartment in… Read more »