Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling in Nanomedicine, Food Safety and Human Health Risk Assessment and Roles of Artificial Intelligence (AI) Approaches in these Areas

ScitoVation News, Webinars

In this presentation, Dr. Zhoumeng Lin introduces how we develop physiologically based pharmacokinetic (PBPK) models of drugs, environmental chemicals and nanoparticles for applications in nanomedicine, food safety, and human health risk assessments. He presents his recent studies to illustrate each application. Dr. Zhoumeng Linalso introduces a new physiological parameter database for PBPK modeling in food-producing animals, including cattle, swine, sheep, …

Chemical structure-property relationships and PBPK modeling: Progress and Perspectives

Amanda Holdan News, Webinars

Dr. Kannan Krishna, Chief of the Air and Site Assessment and Climate indicators Branch (ASACIB) at the Office of Environmental Health Hazard Assessment (OEHHA) of California Environmental Protection Agency, will reflect the ground-breaking work over the past 30 years in the area of chemical structure property relationships and PBPK modeling and the current thinking about way forward. What you’ll learn:  …

Descriptive words blog

The Need for Increased Maturity in the Risk Assessment Ecosystem

ScitoVation Blog

by Dr. Jean Orelien Last year, the US EPA declared they would phase away from animal testing by 2035. Reaching this milestone will require the maturity of the risk assessment ecosystem. By maturity, I mean new roles need to be assumed along with improved interactions and (stronger) bonds within and between group as well as new entities. In this post, I share a …

Physiologically Based Pharmacokinetic (PBPK) Modeling of Central Nervous System

ScitoVation Blog

by Marjory Moreau, Ph.D. I have worked in PBPK modeling for many years and until a few months ago, I never had to deal with the brain compartment. Well, I had a brain compartment in several of my models, but I never really thought about the blood brain barrier and all the transporters involved in protecting or bringing compounds into the brain until recently. I …

What are NAMs?

ScitoVation Blog

by Sage Corzine If you got pumped up about NAMs in a toxicology webinar, tried to find more information on Google, and got redirected to the North American Menopause Society, you are not alone. NAMs or New Approach Methodologies are a vital and growing part of chemical hazard and risk assessment research. Here are a few fun facts that Google …

The Frontier of Aerosol Safety Testing with In Vitro and in Silico Methods

ScitoVation Blog

by Scott Slattery In May and June of this year, the annual Webinar Series on Inhalation Toxicity Testing was co-hosted by The US EPA, the PETA Science Consortium International, Syngenta, and Unilever. The nine webinars presented over three days provided an excellent look at current progress in the area of non-animal inhalation toxicity testing approaches. The talks covered the breadth of the field, addressing in vitro …

Cardiac Toxicity Evaluation with a Human Tissue-Engineered Model

Amanda Holdan News, Webinars

Dr. Kareen Coulombe joined us to share her latest findings for assessing cardiac toxicity using a predictive 3D human cardiac microtissue platform for assessing toxicity of chemical compounds.   What you’ll learn:  How NAM’s are used to assess cardiac toxicity How human 3-D cardiac microtissue systems can address limitations of traditional in vivo and in vitro assays in predicting arrhythmia generation …

Why ScitoVation is Part of my Journey

ScitoVation Blog

Dr. Jean Orelien, CEO My passion is helping solve problems at the intersection of health, science, and technology. In other words, problems for which we can use science and technology to improve lives. With ScitoVation, our long-term vision is to achieve this by helping our clients develop safe chemicals for humans and the environment using innovative science and technology. There are parallels between our work at ScitoVation and SciMetrika, the first company I founded  in 2004 and sold in 2018. At SciMetrika, we used …

Updated Guidance from OECD on Reporting PBPK Models for Risk Assessment

Amanda Holdan Blog

As an advocate in PBPK modeling for risk assessment, I want to share with you the latest guidance from the Organization of Economic Cooperation and Development (OECD). I write a lot of reports on PBPK models for clients, and it makes a huge difference to always use the same format to report the goal of the project, the development of the PBPK model and how it will be used. It makes my life easier and obviously the client appreciates being able to follow and understand …