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ScitoVation Senior Research Fellow receives 2022 Arnold J. Lehman Award from the Society of Toxicology.

Amanda Holdan Blog

Posted by Dr. Mel Andersen, Senior Research Fellow, ScitoVation.    ScitoVation is pleased to announce that Senior Research Fellow, Dr. Jeffrey W. Fisher (Jeff) is the recipient of the 2022 Arnold J. Lehman Award from the Society of Toxicology (SOT). SOT is a professional and scholarly organization of scientists from academic institutions, government, and industry with membership from both the …

Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling in Nanomedicine, Food Safety and Human Health Risk Assessment and Roles of Artificial Intelligence (AI) Approaches in these Areas

ScitoVation News, Webinars

In this presentation, Dr. Zhoumeng Lin introduces how we develop physiologically based pharmacokinetic (PBPK) models of drugs, environmental chemicals and nanoparticles for applications in nanomedicine, food safety, and human health risk assessments. He presents his recent studies to illustrate each application. Dr. Zhoumeng Linalso introduces a new physiological parameter database for PBPK modeling in food-producing animals, including cattle, swine, sheep, …

Chemical structure-property relationships and PBPK modeling: Progress and Perspectives

Amanda Holdan News, Webinars

Dr. Kannan Krishna, Chief of the Air and Site Assessment and Climate indicators Branch (ASACIB) at the Office of Environmental Health Hazard Assessment (OEHHA) of California Environmental Protection Agency, will reflect the ground-breaking work over the past 30 years in the area of chemical structure property relationships and PBPK modeling and the current thinking about way forward. What you’ll learn:  …

Clinical Pharmacology During Pregnancy Book Cover

Upcoming Book Release: Clinical Pharmacology during Pregnancy, second edition, September 24, 2021 

ScitoVation Blog

by Jeff Fisher   Edited by  Donald Mattison   Lee-Ann Halbert  I was the senior author of one chapter in the newly released textbook, “Clinical Pharmacology During Pregnancy, second edition.”  Coauthors on the original research publications include scientists from the US FDA, Duke University, and Proctor & Gamble Corporation.  The editors were Dr Donald Mattison and Ms. Lee-Ann Halbert.  Dr Mattison, a physician/researcher has been a strong advocate of computational methods in the field of toxicology throughout his distinguished career with a focus …

A graph showing value of KMD

The Importance of using Kinetically Derived Maximum Dose (KMD)

ScitoVation Blog

KMD allows for design of in-life experiments that are not confounded by non-linear effects, including saturation of absorption processes. This results in a data package that is more easily interpreted because of its increased relevance to human exposures.  by Jeff Fisher For those who design repeated dose, subchronic and chronic animal toxicity studies, this concept may be an additional responsibility for you.  Gone are the …

3D heart

New Approach Methodologies for Environmental Cardiotoxicity Testing

ScitoVation Blog

by Marjory Moreau Recently I attended  a webinar on “Cardiac toxicity Evaluation with a human tissue-engineered model” by Kareen Coulombe, professor at Brown University. I am still blown away every time I hear Dr. Coulombe speak on this subject. In addition to being an excellent speaker, the work she and her team are doing is incredible. I recently wrote a blog on the brain and all its complexity because the brain is not an organ I had worked …

Alternatives to Animal Testing

Toward More Efficient Safety Testing Through Development of an Internal Threshold of Toxicological Concern

ScitoVation Blog

by Alina Y. Efremenko One of my memorable moments when I was a teenager was my family’s trip to the Grand Canyon. That was my first experience riding a horse. I begged my grandfather to come with me, and reluctantly he agreed. I asked him why he disliked the idea so much and he said, “No one asked the horses.” …

My Summer Internship with ScitoVation

ScitoVation Blog

by Gustavo Nativio Hey there! I‘m the resident intern here at ScitoVation for the summer. As someone deeply interested in systems biology and solving biological problems using mathematics and computational models, the work done by ScitoVation is fascinating to me. ScitoVation is using innovative computational modeling of physiological systems to improve regulation efficiency in the pharmaceutical industry and in the environmental health field!  I work with Physiologically Based Pharmacokinetic (PBPK) modeling. PBPK modeling is a tool to predict the distribution and fate of drugs within an organism. PBPK …

Physiologically Based Pharmacokinetic (PBPK) Modeling of Central Nervous System

ScitoVation Blog

by Marjory Moreau, Ph.D. I have worked in PBPK modeling for many years and until a few months ago, I never had to deal with the brain compartment. Well, I had a brain compartment in several of my models, but I never really thought about the blood brain barrier and all the transporters involved in protecting or bringing compounds into the brain until recently. I …