21st Century Respiratory Toxicology: Complex 3-dimensional Test Systems Provide Human-relevant Data and Will Benefit from Standardization Efforts

Amanda Holdan News, Webinars

Please join us for our next webinar installment with Dr. Holger Behrsing who will provide an overview of respiratory toxicology and discuss the different types of test systems that provide more relevant data and benefits.    What you’ll learn:  Exposure to in vitro/ex vivo pulmonary models used to evaluation complex human pulmonary adverse events How 3D test systems differ and …

Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling in Nanomedicine, Food Safety and Human Health Risk Assessment and Roles of Artificial Intelligence (AI) Approaches in these Areas

ScitoVation News, Webinars

In this presentation, Dr. Zhoumeng Lin introduces how we develop physiologically based pharmacokinetic (PBPK) models of drugs, environmental chemicals and nanoparticles for applications in nanomedicine, food safety, and human health risk assessments. He presents his recent studies to illustrate each application. Dr. Zhoumeng Linalso introduces a new physiological parameter database for PBPK modeling in food-producing animals, including cattle, swine, sheep, …

Chemical structure-property relationships and PBPK modeling: Progress and Perspectives

Amanda Holdan News, Webinars

Dr. Kannan Krishna, Chief of the Air and Site Assessment and Climate indicators Branch (ASACIB) at the Office of Environmental Health Hazard Assessment (OEHHA) of California Environmental Protection Agency, will reflect the ground-breaking work over the past 30 years in the area of chemical structure property relationships and PBPK modeling and the current thinking about way forward. What you’ll learn:  …

representing 3D liver models

Exploring In Vitro 3D Liver Models: Complexity Demands Different Needs

ScitoVation Blog

by Aarati Ranade Every time we perform an experiment with hepatocytes, I am curious to see how the culture looks over time after plating the cells. I carefully place the cell culture plate under the microscope. I carefully observe through the microscope eyepiece. The transition from round cells to formation of flat, hexagonal cells with one or two prominent nuclei with cell borders nicely touching each other to form a carpet-like monolayer …

Alternatives to Animal Testing

Toward More Efficient Safety Testing Through Development of an Internal Threshold of Toxicological Concern

ScitoVation Blog

by Alina Y. Efremenko One of my memorable moments when I was a teenager was my family’s trip to the Grand Canyon. That was my first experience riding a horse. I begged my grandfather to come with me, and reluctantly he agreed. I asked him why he disliked the idea so much and he said, “No one asked the horses.” …

The Frontier of Aerosol Safety Testing with In Vitro and in Silico Methods

ScitoVation Blog

by Scott Slattery In May and June of this year, the annual Webinar Series on Inhalation Toxicity Testing was co-hosted by The US EPA, the PETA Science Consortium International, Syngenta, and Unilever. The nine webinars presented over three days provided an excellent look at current progress in the area of non-animal inhalation toxicity testing approaches. The talks covered the breadth of the field, addressing in vitro …

Using Cells and Mathematical Models to Interpret Thyroid Hormone Disruption

Jeff Blog

by Jeff Fisher This story begins in 1998 when I reviewed a technical document for the chemical perchlorate, now known to be widely distributed in the environment on earth and has been found in high concentrations on Mars.  In 1998, the subject of this document was a proposed safe drinking water level for perchlorate based on historic medical use of perchlorate as a probe of thyroid function,  in the diagnostic called the thyroid discharge test.  This document changed …

“Advancing Neurotoxicity Screening of Environmental Compounds for Public Health Protection.”

Amanda Holdan News, Webinars

Mamta Behl, M.S, Ph.D, D.A.B.T, explores the latest developments in neurotoxicity models. This method uses a combination of in vitro, in vivo extrapolation, and exposure assessment to rapidly screen compounds with neurotoxic potential and disseminate information in a timely manner for  public health.  What you’ll learn:  A survey of the promising in vitro neurotoxic models How well these models have performed Use …