In vitro to in vivo extrapolation

Use of quantitative in vitro to in vivo extrapolation (QIVIVE) for the assessment of non-combustible next-generation product aerosols

Amanda Holdan News, Publication

Marjory Moreau1*  Liam Simms2 Melvin E. Andersen1 Edgar Trelles Sticken3 Roman Wieczorek3 Sarah Jean Pour3 Fiona Chapman2 Karin Roewer3 Sandra Otte3 Jeffrey Fisher1 Matthew Stevenson2Roman Wieczorek3 (1) ScitoVation, LLC, Research Triangle Park, NC 27713, USA (2) Imperial Brands, PLC, Bristol, United Kingdom (3) Reemtsma Cigarettenfabriken GmbH, An Imperial Brands PLC Company, Hamburg, Germany Abstract: With the use of in vitro new approach …

Towards translating in vitro measures of thyroid hormone system disruption to in vivo responses in the pregnant rat via a biologically based dose response (BBDR) model

Amanda Holdan News, Publication

Jeffrey Fisher (a,*), Conrad Housand (b) David Mattie (c), Andy Nong (a), Marjory Moreau (a), Mary Gilbert (d) (a) ScitoVation, LLC, Research Triangle Park, NC 27713, USA (b) Magnolia Sciences, Winter Springs, FL, United States of America (c) AFRL/711 HPW/RHBAF, WPAFB, OH, United States of America (d) Office of Research and Development, Center for Public Health and Environmental Assessment, US …

Graphic from Moreau et al.

Animal-free assessment of developmental toxicity: Combining PBPK modeling with the ReproTracker assay

Amanda Holdan News, Publication

Marjory Moreau (a,*,1), Amer Jamalpoor (b,1,) John Carter Hall (a), Jeffrey Fisher (a), Sabine Hartvelt (b), Giel Hendriks (b), Andy Nong (a), Todor Antonijevic (a) (a) ScitoVation, LLC, Research Triangle Park, NC 27713, USA (b) Toxys, Leiden Bioscience Park, Oegstgeest, the Netherlands   Abstract: in vitro screening platforms to assess teratogenic potential of compounds are emerging rapidly. ReproTracker is a …