by Marjory Moreau, Ph.D. I have worked in PBPK modeling for many years and until a few months ago, I never had to deal with the brain compartment. Well, I had a brain compartment in several of my models, but I never really thought about the blood brain barrier and all the transporters involved in protecting or bringing compounds into the brain until recently. I …
by Sage Corzine If you got pumped up about NAMs in a toxicology webinar, tried to find more information on Google, and got redirected to the North American Menopause Society, you are not alone. NAMs or New Approach Methodologies are a vital and growing part of chemical hazard and risk assessment research. Here are a few fun facts …
by Scott Slattery In May and June of this year, the annual Webinar Series on Inhalation Toxicity Testing was co-hosted by The US EPA, the PETA Science Consortium International, Syngenta, and Unilever. The nine webinars presented over three days provided an excellent look at current progress in the area of non-animal inhalation toxicity testing approaches. The talks covered the breadth of the field, addressing in …
Dr. Kareen Coulombe joined us to share her latest findings for assessing cardiac toxicity using a predictive 3D human cardiac microtissue platform for assessing toxicity of chemical compounds. What you’ll learn: How NAM’s are used to assess cardiac toxicity How human 3-D cardiac microtissue systems can address limitations of traditional in vivo and in vitro assays in predicting arrhythmia generation …
Dr. Jean Orelien, CEO My passion is helping solve problems at the intersection of health, science, and technology. In other words, problems for which we can use science and technology to improve lives. With ScitoVation, our long-term vision is to achieve this by helping our clients develop safe chemicals for humans and the environment using innovative science and technology. There are parallels between our work at ScitoVation and SciMetrika, the first company I founded in 2004 and sold in 2018. At SciMetrika, we used …
As an advocate in PBPK modeling for risk assessment, I want to share with you the latest guidance from the Organization of Economic Cooperation and Development (OECD). I write a lot of reports on PBPK models for clients, and it makes a huge difference to always use the same format to report the goal of the project, the development of the PBPK model and how it will be used. It makes my life easier and obviously the client appreciates being able to follow and understand …