Marjory Moreau1* Liam Simms2 Melvin E. Andersen1 Edgar Trelles Sticken3 Roman Wieczorek3 Sarah Jean Pour3 Fiona Chapman2 Karin Roewer3 Sandra Otte3 Jeffrey Fisher1 Matthew Stevenson2Roman Wieczorek3 (1) ScitoVation, LLC, Research Triangle Park, NC 27713, USA (2) Imperial Brands, PLC, Bristol, United Kingdom (3) Reemtsma Cigarettenfabriken GmbH, An Imperial Brands PLC Company, Hamburg, Germany Abstract: With the use of in vitro new approach …
DURHAM, N.C. (PRWEB) July 11, 2023: ScitoVation is the recipient of the National Institute of Environmental Health Science (NIEHS) Small Business Innovation Research (SBIR) Phase I award of $269,977. The SBIR program is a highly competitive program that encourages domestic small businesses to engage in Federal Research/Research and Development (R/R&D) with the potential for commercialization; enabling small businesses to explore …
Posted by Dr. Mel Andersen, Senior Research Fellow, ScitoVation. ScitoVation is pleased to announce that Senior Research Fellow, Dr. Jeffrey W. Fisher (Jeff) is the recipient of the 2022 Arnold J. Lehman Award from the Society of Toxicology (SOT). SOT is a professional and scholarly organization of scientists from academic institutions, government, and industry with membership from both the …
In this presentation, Dr. Zhoumeng Lin introduces how we develop physiologically based pharmacokinetic (PBPK) models of drugs, environmental chemicals and nanoparticles for applications in nanomedicine, food safety, and human health risk assessments. He presents his recent studies to illustrate each application. Dr. Zhoumeng Linalso introduces a new physiological parameter database for PBPK modeling in food-producing animals, including cattle, swine, sheep, …
by Jeff Fisher Edited by Donald Mattison Lee-Ann Halbert I was the senior author of one chapter in the newly released textbook, “Clinical Pharmacology During Pregnancy, second edition.” Coauthors on the original research publications include scientists from the US FDA, Duke University, and Proctor & Gamble Corporation. The editors were Dr Donald Mattison and Ms. Lee-Ann Halbert. Dr Mattison, a physician/researcher has been a strong advocate of computational methods in the field of toxicology throughout his distinguished career with a focus …
KMD allows for design of in-life experiments that are not confounded by non-linear effects, including saturation of absorption processes. This results in a data package that is more easily interpreted because of its increased relevance to human exposures. by Jeff Fisher For those who design repeated dose, subchronic and chronic animal toxicity studies, this concept may be an additional responsibility for you. Gone are …
by Marjory Moreau Recently I attended a webinar on “Cardiac toxicity Evaluation with a human tissue-engineered model” by Kareen Coulombe, professor at Brown University. I am still blown away every time I hear Dr. Coulombe speak on this subject. In addition to being an excellent speaker, the work she and her team are doing is incredible. I recently wrote a blog on the brain and all its complexity because the brain is not an organ I had worked …
by Alina Y. Efremenko One of my memorable moments when I was a teenager was my family’s trip to the Grand Canyon. That was my first experience riding a horse. I begged my grandfather to come with me, and reluctantly he agreed. I asked him why he disliked the idea so much and he said, “No one asked the horses.” …
by Gustavo Nativio Hey there! I‘m the resident intern here at ScitoVation for the summer. As someone deeply interested in systems biology and solving biological problems using mathematics and computational models, the work done by ScitoVation is fascinating to me. ScitoVation is using innovative computational modeling of physiological systems to improve regulation efficiency in the pharmaceutical industry and in the environmental health field! I work with Physiologically Based Pharmacokinetic (PBPK) modeling. PBPK modeling is a tool to predict the distribution and fate of drugs within an organism. PBPK …