Our webinar on PBPK Modeling features speakers Dr. Steven Webb and Dr. David Cowie from Syngenta. Together, they will share models to assess how Tyrosine aminotransferase (TAT) catalyzes the conversion of tyrosine to accumulation of hydroxyphenylpyruvic acid (HPPA) and how its activity varies among mammalian species. Species differences also exist in the ability to utilize alternative pathways for tyrosine catabolism …
We are excited to present our first recorded installment for our 2024 webinar series. Jeff Fisher, PhD, ScitoVation’s Senior Science Fellow, will be speaking about thyroid disruption and IVIVE based on his latest publication. ScitoVation scientists continue advancing the benefits of IVIVE modeling. What you’ll learn: Thyroid modeling demonstrating IVIVE for a molecular initiating event determined in vitro How to …
Jeffrey Fisher (a,*), Conrad Housand (b) David Mattie (c), Andy Nong (a), Marjory Moreau (a), Mary Gilbert (d) (a) ScitoVation, LLC, Research Triangle Park, NC 27713, USA (b) Magnolia Sciences, Winter Springs, FL, United States of America (c) AFRL/711 HPW/RHBAF, WPAFB, OH, United States of America (d) Office of Research and Development, Center for Public Health and Environmental Assessment, US …
Marjory Moreau (a,*,1), Amer Jamalpoor (b,1,) John Carter Hall (a), Jeffrey Fisher (a), Sabine Hartvelt (b), Giel Hendriks (b), Andy Nong (a), Todor Antonijevic (a) (a) ScitoVation, LLC, Research Triangle Park, NC 27713, USA (b) Toxys, Leiden Bioscience Park, Oegstgeest, the Netherlands Abstract: in vitro screening platforms to assess teratogenic potential of compounds are emerging rapidly. ReproTracker is a …
Our speaker is Dustin Kapraun, PhD, physical scientist with the Center for Public Health and Environmental Assessment (CPHEA) in the Office of Research and Development (ORD) at the U.S. Environmental Protection Agency (EPA). In developing human health risk assessments, it is important to consider pregnant women, developing fetuses, and nursing children because chemical exposures experienced by these groups can lead …
Artificial Intelligence (AI) is impacting all types of work, including toxicology. Dr Hartung will discuss how to move toxicology to a more holistic and integrated paradigm using AI and how AI plays a role in setting the direction of “Toxicology for the 21st Century 2.0” in future decades. What you’ll learn: Sources of Big Data for toxicology and various AI …
We just had a wonderful talk from Dr. Dan Hoer. Dr Hoer is a physical scientist with the US Environmental Protection Agency, Office of Pesticide Programs. His talk will focus on non-linear PBPK modeling, and the advantages offered by this approach. What you’ll learn: Important advantages of PBPK modeling over statistical methods that are often restricted to bimodal distinctions of …