Towards translating in vitro measures of thyroid hormone system disruption to in vivo responses in the pregnant rat via a biologically based dose response (BBDR) model

Amanda HoldanNews, Publication

Jeffrey Fisher (a,*), Conrad Housand (b) David Mattie (c), Andy Nong (a), Marjory Moreau (a), Mary Gilbert (d) (a) ScitoVation, LLC, Research Triangle Park, NC 27713, USA (b) Magnolia Sciences, Winter Springs, FL, United States of America (c) AFRL/711 HPW/RHBAF, WPAFB, OH, United States of America (d) Office of Research and Development, Center for Public Health and Environmental Assessment, US …

Using Cells and Mathematical Models to Interpret Thyroid Hormone Disruption

JeffBlog

by Jeff Fisher This story begins in 1998 when I reviewed a technical document for the chemical perchlorate, now known to be widely distributed in the environment on earth and has been found in high concentrations on Mars.  In 1998, the subject of this document was a proposed safe drinking water level for perchlorate based on historic medical use of perchlorate as a probe of thyroid function,  in the diagnostic called the thyroid discharge test.  This document changed …