Using the PBK Model to Predict Risk Metrics: MOIE, MOS

Systems PBK/PD Modeling of 4-Hydroxyphenylpyruvate Dioxygenase Inhibition

Amanda HoldanNews, Webinars

 Our webinar on PBPK Modeling features speakers Dr. Steven Webb and Dr. David Cowie from Syngenta. Together, they will share models to assess how Tyrosine aminotransferase (TAT) catalyzes the conversion of tyrosine to accumulation of hydroxyphenylpyruvic acid (HPPA) and how its activity varies among mammalian species. Species differences also exist in the ability to utilize alternative pathways for tyrosine catabolism …