February 18, 2025 – Durham, North Carolina: ScitoVation, a pioneer in New Approach Methodologies (NAMs), today announced a strategic decision to fully focus on advancing software tools and computational services to help clients assess the safety of compounds (in silico). By directing attention to its core strengths, ScitoVation aims to bolster its competitive edge and deliver even greater value to the …
Systems PBK/PD Modeling of 4-Hydroxyphenylpyruvate Dioxygenase Inhibition
Our webinar on PBPK Modeling features speakers Dr. Steven Webb and Dr. David Cowie from Syngenta. Together, they will share models to assess how Tyrosine aminotransferase (TAT) catalyzes the conversion of tyrosine to accumulation of hydroxyphenylpyruvic acid (HPPA) and how its activity varies among mammalian species. Species differences also exist in the ability to utilize alternative pathways for tyrosine catabolism …