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Safety assessment strategies that rely on testing species-relevant cells in vitro are advancing, yet there are currently no in vitro alternatives for hepatotoxicity testing accepted by regulators. An organotypic rat model, capable of predicting rat in vivo responses to hepatotoxicants, will provide an affordable and ethical alternative to in vivo rat models currently utilized. An ideal in vitro liver model for hepatotoxicity testing would include hepatocytes and the non-parenchymal cells (NPCs) (i.e., hepatic stellate cells, Kupffer cells, and liver sinusoidal endothelial cells), and would support…Read more »

Gene expression profiling is emerging as a viable way to evaluate mode of action and points of departure and has the potential to drastically reduce testing costs and product development time. The first steps of using transcriptional responses as a basis of safety assessment are being taken. However, several important considerations remain unresolved, including how to translate expression changes into adverse outcome pathways or other definitions of mode of action…Read more »

As part of its annual Clarenburg Lecture Series, the College of Veterinary Medicine will host Melvin “Mel” Andersen at 4 p.m. Tuesday, Oct. 8, in the Mara Conference Center on… Read more »

 ScitoVation, pioneers in chemical safety assessment, and a rapidly growing life sciences solution company based in the Research Triangle Park, North Carolina, today announced the appointment of Shiloh J. Barfield… Read more »

ScitoVation launched its new Collaborative Partnering Program (CPP) designed to engage industry consultants to promote the use of 21st-century safety assessment methods and new alternative methods (NAMS) with their clients.… Read more »

Dr. Moreau – Manager of the company’s PBPK (Physiologically based pharmacokinetic modeling) division has been selected to receive the 2019 Health Products, and Food Branch Assistant Deputy Minister’s Award for… Read more »