Latest News

Hepatotoxic Response in 2D and 3D Co-culture Models Differs From Hepatocyte-alone Models

Safety assessment strategies that rely on testing species-relevant cells in vitro are advancing, yet there are currently no in vitro alternatives for hepatotoxicity testing accepted by regulators. An organotypic rat model, capable of predicting rat in vivo responses to hepatotoxicants, will provide an affordable and ethical alternative to in vivo rat models currently utilized. An ideal in vitro liver model for hepatotoxicity testing would include hepatocytes and the non-parenchymal cells (NPCs) (i.e., hepatic stellate cells, Kupffer cells, and liver sinusoidal endothelial cells), and would support…Read more »

Integration of Transcriptomic Point of Departure Metrics Into the MoAviz Visualization Framework

Gene expression profiling is emerging as a viable way to evaluate mode of action and points of departure and has the potential to drastically reduce testing costs and product development time. The first steps of using transcriptional responses as a basis of safety assessment are being taken. However, several important considerations remain unresolved, including how to translate expression changes into adverse outcome pathways or other definitions of mode of action…Read more »

ScitoVation Announces Release of PLETHEM

Software to Integrate Chemical Exposures and Health Effects Durham, N.C., March 25, 2019—ScitoVation, a solution leader recognized as an industry expert in cell-based assays and computational methods, today announced the… Read more »

Visit us at SoT 2019

ScitoVation will be attending the 2019 Society of Toxicology (SoT) conference in Baltimore on March 10-14. Visit us at booth 3218 in the exhibit hall, or see one of our… Read more »

Announcing ScitoXpress

Identifying Lowest Dosage where Bioactivity Occurs and Mode of Action ScitoVation is pleased to introduce the ScitoXpress™ package, enabling us to conduct in vitro transcriptomics studies on client compounds to… Read more »