chemical structures

Chemical structure-property relationships and PBPK modeling: Progress and Perspectives

Amanda Holdan News, Webinars

  Please join us for our next webinar on November 9 at 11am ET by Dr. Kannan Krishnan, Chief of the Air and Site Assessment and Climate indicators Branch (ASACIB) at the Office of Environmental Health Hazard Assessment (OEHHA) of California Environmental Protection Agency. He will take us through the journey of his lab’s work on chemical structure-property relationships for PBPK modeling …

Cholestasis Classification by logistic regression

Development of a Molecular Fingerprint for Predicting Drug-induced Cholestasis

ScitoVation News, Webinars

Jake Reske, ScitoVation graduate intern in toxicogenomics, will explains a meta-analysis strategy used to develop a preliminary classifier of hepatic cholestasis through public transcriptomic data sets. Cholestasis is a hepatic disease that results from bile acid metabolic dysregulation. We describe our approach to using transcriptomics, statistical modeling, and machine learning to identify molecular signatures of cholestasis. What you’ll learn:  Data-driven approaches to identify …