Using Transcriptomic Points of Departure to Determine Compound Toxicity

Amanda Holdan Uncategorized

Conventional concepts of points of departure for adverse effects (e.g., NOAEL/LOAEL) do not translate directly to gene expression data. The benchmark dose approach offers a robust alternative method, and has been adapted to transcriptomics.  Benchmark Dose is a data driven mathematical approach to determine a dose at which a significant change in response is detected. It is applicable to continuous data such as gene expression data where …