Application of Toxicokinetics Modeling for the Prioritization of Chemical Groupings

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Abstract

Health Canada has been studying the applications of new alternative methods (NAMs) for the next generation of risk assessment.  Under Canada’s Chemicals Management Plan (CMP), scientists and regulators have been partnering together to develop series of case studies and research initiatives at using high throughput toxicity testing content for the prediction of potential biological changes leading into harmful health effects.  

Toxicokinetics plays a key part in connecting in vitro test concentrations with exposure levels that can be regulated.  In this presentation, we will see different research scenarios where toxicokinetic modeling was involved converting dose exposure for purposes of priority setting and screening-level risk assessment of chemicals classes.  The examples will range from rare earth metals, in-commerce list, and domestic substance list and polyfluoroalkyl substances.  We will find out how the development of predictive tools and informed utility of non-traditional toxicity data is being viewed in a regulatory decision-making context.  
 

Dr. Andy Nong

Dr. Andy Nong is the Principle Research Scientist for the Computational Toxicology Laboratory at Health Canada Environmental Health Sciences and Research Bureau. He received his PhD in Public Health from University of Montreal. Afterwards, he was formerly a Postdoctoral Fellow and Research Investigator at the Chemical Industry Institute of Toxicology/The Hamner Institutes for Health Sciences. At Health Canada, Dr Nong has been developing toxicokinetic and biological modeling research to advance alternative risk assessment approaches.  He has also helped developed Biomonitoring Equivalents to interpret biomonitoring data with the Canadian Health Measures Survey and more recently is working at evaluating computer tools for the in vitro to in vivo extrapolation of high throughput screening content for Health Canada Chemical Management Plan. He has author/co-author of over 50 publications including peer-reviewed articles and book chapters, and once served on the Board of Editors of the Journal of Applied Toxicology.  In addition to his research activities, Dr Nong currently serves as president for the Society of Toxicology Biological Modeling Speciality Section.  He also has been involved in many expert committees such as the National Academies of Sciences (NAS), World Health Organisation International Programme on Chemical Safety (WHO/IPCS), Organisation for Economic Co-operation and Development (OECD), and European Union Reference Laboratory for alternatives to animal testing (EURL-ECVAM).