Scientific consulting + ScitoSim
Make Sound, Human-Relevant Safety Decisions Faster
Integrated PBPK/qIVIVE, transcriptomics, mode-of-action and computational toxicology services for chemicals, pesticides, consumer-product ingredients and pharmaceuticals.
When a study produces a biological signal, a compound approaches regulatory review or an exposure question remains unresolved, ScitoVation brings the evidence, biology and dosimetry together.
Schedule a Scientific Consultation
Scientific consultation
Discuss Your Compound or Study
Tell us how to reach you. A ScitoVation scientist will follow up to understand your question and timeline.
Submission does not create a consulting relationship or guarantee project acceptance.
From findings to clarity
Fragmented Evidence Makes Important Safety Decisions Slower and Harder
Chemical-safety questions are rarely solved by one dataset or model. Literature may be incomplete, a response may not translate directly to realistic human exposure, and separate vendors may address each evidence stream without a consistent method connecting the results.
ScitoVation provides the scientific expertise and integrated technology needed to move from a collection of findings to a clear, human-relevant assessment.
Start with the decision
What Question Does Your Team Need to Answer?
Is This Finding Relevant to Humans?
Connect biological response, mechanism and realistic exposure to determine whether an observed finding should change the safety decision.
What Human Dose Does the Study Represent?
Use PBPK modeling, qIVIVE, reverse dosimetry and route-to-route extrapolation to translate experimental concentrations into human-relevant exposure.
What Does the Transcriptomic Signal Mean?
Identify points of departure, pathways, biomarkers and mode-of-action evidence that clarify the biological response.
What Evidence Is Missing Before Review?
Synthesize current literature and internal data, identify remaining uncertainty and determine which analysis can address the most consequential gap.
Which Compounds Require Attention First?
Apply a consistent framework across a portfolio to prioritize chemicals, data needs and next actions.
Can the Methodology Be Traced and Reproduced?
Create a connected record from source evidence through analysis and interpretation, supporting scientific review and communication.
Integrated scientific services
One Team. Connected Evidence. Clearer Decisions.
Our scientists select the level of analysis that fits the question—then connect evidence, biology and exposure in one coherent workflow.
PBPK Modeling, qIVIVE and Human-Dose Prediction
Translate in vitro and animal-study results into human-relevant exposure estimates using tier-appropriate PBPK models, reverse dosimetry and route-to-route analysis.
Transcriptomics and Mode-of-Action Analysis
Identify points of departure, biological pathways, biomarkers, similarity to other compounds and potential modes of action using transcriptomic evidence.
Information Synthesis and Evidence Mapping
Bring published studies, regulatory information and internal evidence into a structured, traceable assessment that reveals consequential data gaps.
Computational Toxicology and NAM Strategy
Apply New Approach Methodologies within a grounded framework connecting evidence synthesis, biological interpretation and dosimetry.
Chemical Risk Assessment and Product Stewardship
Support regulatory review, portfolio prioritization and safety decisions with an assessment designed around the compound, use and exposure scenario.
How we work
One Scientific Workflow From Evidence to Decision
- 1
Frame the Decision
Share the compound, study, biological finding, regulatory concern or portfolio question.
- 2
Map the Evidence
We identify what is known and what remains uncertain.
- 3
Apply the Right Methods
Use information synthesis, transcriptomics, PBPK/qIVIVE or an integrated combination.
- 4
Interpret Human Relevance
Connect biological response and human exposure.
- 5
Move Forward
Receive organized outputs, transparent methods and clear recommendations.
Built for scientific teams
Human-Relevant Safety Decisions Carry Real Consequences
ScitoVation supports product stewardship and safety professionals, heads of toxicology, regulatory affairs leaders, EHS teams, risk-assessment scientists, R&D leaders, bioinformaticians and PBPK modelers.
Priority organizations include chemical and specialty-chemical manufacturers, agricultural-chemical and pesticide companies, consumer-product and ingredient companies, pharmaceutical and biotechnology organizations, associations and consortia.
Scientific foundation
Rigor You Can Trace
ScitoSim implements the tiered NAMs framework described in Andersen et al. (2019), published in ALTEX.
The framework was co-developed through the American Chemistry Council Long Range Research Initiative.
Information synthesis, transcriptomics and PBPK modeling operate within one connected workflow.
ScitoSim incorporates a 20,000-compound database, including EPA ToxCast transcriptomics data.
ScitoSim supports scientific judgment; it does not replace it. Regulatory acceptance depends on the question, evidence, methods, jurisdiction and reviewing authority, and is not guaranteed.
Frequently asked questions
Answers Before We Begin
Does ScitoVation provide scientific services, software or both?
Both. ScitoVation scientists can perform the analysis and interpretation as a service using ScitoSim. Platform-access options may also be available for qualified scientific teams and collaborators.
Can you work with our internal data?
Yes. The initial consultation determines which literature, study data, exposure information, transcriptomic results or modeling inputs are available and appropriate.
Do we need to know which service we require before contacting you?
No. Begin with the compound, finding, regulatory issue or decision. We will help determine the appropriate approach.
Can ScitoVation support regulatory decision-making?
Yes. Work can support regulatory and product-stewardship decisions using transparent scientific methods. No provider can guarantee acceptance by a particular authority.
Bring us the question
Turn Scientific Uncertainty Into a Clear Next Step
We will help frame the problem, identify the analysis that can reduce uncertainty and determine the clearest path forward.
Scientific consultation