Melvin E. Andersen Biomarkers of exposure can be measured at lower and lower levels due to advances in analytical chemistry. Using these highly sensitive methods, some epidemiology studies report associations between plasma and urinary biomarkers and health outcomes at biomarker levels much below those associated with effects in animal studies. In some cases, these associations may arise from pharmacokinetic (PK) bias, i.e., a situation where a confounding …
Better alternative models for risk assessment: In vitro inhalation toxicity assay and dosimetry modeling
Last week, my colleague, Scott Slattery, presented a webinar on in vitro inhalation point-of-contact toxicity testing with vapors. It brought me back to when I started working with Scott last year on this project. As a physiologically based pharmacokinetic modeler, the only time I worked in a lab…
In Vitro Inhalation Point-of-Contact Toxicity Testing with Vapors
Join us on Thursday, April 29th, at 11am for a webinar highlighting alternatives to in vivo animal testing that instead leverage PBPK modeling. This webinar will be presented by Dr. Scott Slattery, a cell biologist at ScitoVation.
ScitoVation Researcher Selected as Finalist
Congratulations to Jake Reske! His abstract on transcriptomic predictive modeling for drug-induced cholestasis with ScitoVation was selected as a finalist for the Environmental Mutagenesis and Genomics Society Bioinformatics Challenge 2021.
Applications of PBPK Modeling in Pesticide Risk Assessment
Thanks to all who joined us on Tuesday, Mar. 30, for a special review of how PBPK modeling can be successfully applied to pesticide risk assessment, presented by Dr. Cecilia Tan, of the US EPA Office of Pesticide Programs. If you missed it, you may view the recording.
Application of Toxicokinetics Modeling for the Prioritization of Chemical Groupings
Our second webinar of 2021 was a huge success, we had more than 275 registrants! If you were unable to join us for this presentation, you are in luck: just click below to access a recording of the event!
PFAS PBPK Models: Current Status and Progress Needed To Predict Hypothalamic-Pituitary-Thyroid Axis Perturbations
PFAS PBPK Models: Current Status and Progress Needed To Predict Hypothalamic-Pituitary-Thyroid Axis Perturbations
Please join us on Monday, Feb. 8, for a special educational webinar presented by Dr. Jeffrey Fisher, Senior Science Fellow for the Computational Biology Division of ScitoVation.
Water Disinfection: Beneficial or Detrimental?
Disinfecting water reduces death by killing waterborne disease. But could the disinfection process also be detrimental to our health?
Development and Application of a Life Stage Physiologically based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans
While insecticides are an essential to many food supply and public health concerns, they are sometimes associated with bioactivity and therefore raise questions about human and environmental health implications. Pyrethroids are insecticides used in household products, agricultural applications and mosquito control. In rat, juveniles were
more sensitive than adults to pyrethroid-driven health effects. The US Environmental Protection Agency (USEPA) raised questions about …Read more »