Mechanistic in silico inference of dermal absorption for chemical risk assessment

Scott Stephanoff Webinars

This is the inaugural session of ScitoVation’s 2022 Webinar Series. We have exciting speakers and topics planned for 2022. John Troutman and Abdullah Hamadeh presented a computational workflow for predicting in vivo dermal absorption by integrating a mechanistic model of skin penetration with in vitro permeation test (IVPT) measurements. What you’ll learn: A Bayesian approach through which posterior distributions of …

Investigating Metabolism Impact of Internal Butylparaben Concentration

Scott Stephanoff Case Studies

Client problem Parabens are widely used as preservatives in products in pharmaceutical, food, and cosmetics. As the general population is exposed every day to a variety of personal care products, risk assessment is necessary to assure safe use of these products. At this time, there is no information showing that parabens that are used in cosmetics influence human health. However, …

Using Transcriptomics to investigate MoA

Scott Stephanoff Case Studies

Key Takeaways: Transcriptomics coupled with in vitro experimental design can provide a cost-efficient way for generating hypotheses on possible mode of actions that can be confirmed in follow-up studies. Additionally, the information on the doses at which transcriptomics change happen from these studies can be used to classify risk level and help guide design of future studies. In sum, transcriptomics …

Use of Computational Approaches to Support Risk Assessment for pyrethroids for Early Life-Stages

Scott Stephanoff Case Studies

Client problem Pyrethroids are among the most commonly used insecticides. Concerns for potentially higher sensitivity to pyrethroid exposure in children arose from previous studies showing that rat juveniles were more sensitive than adults to pyrethroids. In response to US Environmental Protection Agency (USEPA) questions about the relevance of the high dose rat data, the Council for the Advancement of Pyrethroid …

The Application Of Benchmark Dose To Toxicogenomic Data

Scott Stephanoff Case Studies

Key Takeaways: Benchmark dose (BMD) analysis offers a cost efficient and rapid means of categorizing the risk associated with a chemical. Using BMD data, margins of exposure can be computed to compare exposure scenarios against exposures that cause transcriptomics changes.  A practical application for BMD is as a screening tool to select from a group of chemicals based on their …