by Patrick McMullen We are pleased to announce our most recent manuscript, A systematic approach to evaluate plausible modes of actions for mouse lung tumors in mice exposed to 4-methylimidazole, published in Regulatory Toxicology and Pharmacology. 4-methylimidazole is a ubiquitous compound present in foods that undergo thermal browning (i.e., Maillard reaction) processes. The work described here—a combined effort of investigators from ScitoVation and ToxStrategies supported by the American Beverage Association—aimed …
Toward an Actionable Collaborative Data System for Toxicology
Patrick McMullen, Director of Computational Toxicology I have often joked that as a computational biologist in an applied field that has been slow to embrace bioinformatics, it is my goal to work myself out of a job. That is, if I can empower the scientific experts responsible for safety decisions with the right tools, then they can ask their questions …
Better alternative models for risk assessment: In vitro inhalation toxicity assay and dosimetry modeling
Last week, my colleague, Scott Slattery, presented a webinar on in vitro inhalation point-of-contact toxicity testing with vapors. It brought me back to when I started working with Scott last year on this project. As a physiologically based pharmacokinetic modeler, the only time I worked in a lab…