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Sep 1, 2017


In this course, you will learn to apply an effective computational tool — physiologically based pharmacokinetic (PBPK) modeling — to translate the results of in vitro toxicity assays into estimates of safe human exposure. This one-week course will cover the principles of PBPK modeling and the application of this technique for in vitro to in vivo extrapolation (IVIVE) to support risk assessments based on non-animal methods. The course features comprehensive lectures and extensive hands-on computer modeling practice. This course will prepare you to use state-of-the-art modeling & simulation techniques to assist in estimating acceptable human exposure guidelines from the results of in vitro toxicity assays.



  • Industrial, pharmaceutical and regulatory scientists desiring to interpret the results of in vitro toxicity assays in terms of their implications for human health

  • Toxicologists and research scientists who develop or conduct in vitro toxicity assays

  • Individuals desiring to learn how to develop and apply PBPK models

  • Individuals interested in promoting the use of alternatives to live animal testing for regulatory requirements such as REACH



  • Tuition

  • Comprehensive take-home course materials

  • Breakfast and Lunch daily

  • Refreshments

  • Certificate of Attendance


*Students will be required to bring a PC laptop computer to the course each day for hands-on modeling exercises.

To register use the following link:


Contact Kevin Causey with questions at