Research and Publications

  • Q Zhang, S Bhattacharya, RB Conolly, HJ Clewell, NE Kaminski, and ME Andersen. Molecular signaling network motifs provide a mechanistic basis for cellular threshold responses. Environ. Health Perspect. 122 (12) : 1261-70 (Dec 12, 2014). [pubmed] [pdf]
  • K Romero, V Sinha, S Allerheiligen, M Danhof, J Pinheiro, N Kruhlak, Y Wang, S-J Wang, J-M Sauer, JF Marier, B Corrigan, J Rogers, Heerspink Lambers, T Gumbo, P Vis, P Watkins, T Morrison, W Gillespie, MF Gordon, D Stephenson, D Hanna, M Pfister, R Lalonde, and T Colatsky. Modeling and simulation for medical product development and evaluation: highlights from the FDA-C-Path-ISOP 2013 workshop J. Pharmacokinet. Pharmacodyn. 41 (6) : 545 -552 (Dec 7, 2014). [pubmed] [upload pdf] -->
  • C Deisenroth, MB Black, L Pluta, SM Witherspoon, PD McMullen, RS Thomas, and SN Pendse. MYC is an early response regulator of human adipogenesis in adipose stem cells. PLoS ONE 9 (12) : e114133 (Dec 1, 2014). [pubmed] [pdf]
  • RA Clewell, B Sun, Y Adeleye, P Carmichael, A Efremenko, S Pendse, OJ Trask, A White, ME Andersen, and PD McMullen. Profiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damage Toxicol. Sci. 142 (1) : 56 -73 (Nov 30, 2014). [pubmed] [pdf]
  • UM Bello, MC Madekurozwa, HB Groenewald, TA Aire, and A Arukwe. The effects on steroidogenesis and histopathology of adult male Japanese quails (Coturnix coturnix japonica) testis following pre-pubertal exposure to di(n-butyl) phthalate (DBP). Comp. Biochem. Physiol. C Toxicol. Pharmacol. 166 : 24-33 (Nov 28, 2014). [pubmed] [pdf]
  • K Yang, JL Woodhead, PB Watkins, BA Howell, and KLR Brouwer. Systems pharmacology modeling predicts delayed presentation and species differences in bile acid-mediated troglitazone hepatotoxicity Clin. Pharmacol. Ther. 96 (5) : 589 -598 (Nov 28, 2014). [pubmed] [upload pdf] -->
  • BA Wetmore, B Allen, HJ Clewell, T Parker, JF Wambaugh, LM Almond, MA Sochaski, and RS Thomas. Incorporating population variability and susceptible subpopulations into dosimetry for high-throughput toxicity testing Toxicol. Sci. 142 (1) : 210 -224 (Nov 21, 2014). [pubmed] [pdf]
  • MB Phillips, M Yoon, B Young, and YM Tan. Analysis of biomarker utility using a PBPK/PD model for carbaryl. Front Pharmacol 5 : 246 (Nov 18, 2014). [pubmed] [upload pdf] -->
  • JL Woodhead, K Yang, SQ Siler, PB Watkins, KL Brouwer, HA Barton, and BA Howell. Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury. Front Pharmacol 5 : 240 (Nov 7, 2014). [pubmed] [pdf]
  • PB Watkins, M Merz, MI Avigan, N Kaplowitz, A Regev, and JR Senior. The Clinical Liver Safety Assessment Best Practices Workshop: Rationale, Goals, Accomplishments and the Future Drug Saf. 37 (1) : 1 -7 (Nov 1, 2014). [pubmed] [upload pdf] -->