Research and Publications

  • FY Bois, M Jamei, and HJ Clewell. PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals Toxicology 278 (3) : 256 -267 (Dec 30, 2010). [pubmed] [upload pdf] -->
  • ME Andersen, HJ Clewell, E Bermudez, DE Dodd, GA Willson, JL Campbell, and RS Thomas. Formaldehyde: Integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound Toxicol. Sci. 118 (2) : 716 -731 (Dec 30, 2010). [pubmed] [pdf]
  • Abrew De, NE Kaminski, and RS Thomas. An integrated genomic analysis of aryl hydrocarbon receptor-mediated inhibition of B-cell differentiation Toxicol. Sci. 118 (2) : 454 -469 (Dec 6, 2010). [pubmed] [upload pdf] -->
  • JD Stewart, R Horvath, E Baruffini, I Ferrero, S Bulst, PB Watkins, RJ Fontana, CP Day, and PF Chinnery. Polymerase ?Gene POLG determines the risk of sodium valproate-induced liver toxicity Hepatology 52 (5) : 1791 -1796 (Nov 1, 2010). [pubmed] [upload pdf] -->
  • F Boellmann, L Zhang, HJ Clewell, GP Schroth, EM Kenyon, ME Andersen, and RS Thomas. Genome-wide analysis of DNA methylation and gene expression changes in the mouse lung following subchronic arsenate exposure Toxicol. Sci. 117 (2) : 404 -417 (Oct 28, 2010). [pubmed] [pdf]
  • DM Rotroff, BA Wetmore, DJ Dix, SS Ferguson, HJ Clewell, KA Houck, EL Lecluyse, ME Andersen, RS Judson, CM Smith, MA Sochaski, RJ Kavlock, F Boellmann, MT Martin, DM Reif, JF Wambaugh, and RS Thomas. Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening Toxicol. Sci. 117 (2) : 348 -358 (Oct 16, 2010). [pubmed] [upload pdf] -->
  • SN Campion, EA Houseman, MA Sandrof, JB Hensley, Y Sui, KW Gaido, Z Wu, and K Boekelheide. Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. II. Gene array analysis reveals adaptive changes in cell cycle and cell death pathways Toxicol. Sci. 117 (2) : 457 -465 (Oct 8, 2010). [pubmed] [upload pdf] -->
  • E Yehuda-Shnaidman, B Buehrer, J Pi, N Kumar, and S Collins. Acute stimulation of white adipocyte respiration by PKA-induced lipolysis Diabetes 59 (10) : 2474 -2483 (Oct 3, 2010). [pubmed] [pdf]
  • J Pi, and S Collins. Reactive oxygen species and uncoupling protein 2 in pancreatic ?-cell function Diabetes Obes. Metab. 12 (SUPPL. 2) : 141 -148 (Oct 1, 2010). [pubmed] [pdf]
  • MW Anders, ME Andersen, HJ Clewell, ML Gargas, FP Guengerich, and RH Reitz. Comment on M.V. Evans and J.C. Caldwell: Evaluation of two different metabolic hypotheses for dichloromethane toxicity using physiologically based pharmacokinetic modeling of in vivo gas uptake data exposure in female B6C3F1 mice, Toxicol. Appl. Pharmacol., 244, 280-290, 2010 Toxicol. Appl. Pharmacol. 248 (1) : 63 -64 (Oct 1, 2010). [pubmed] [upload pdf] -->