Population Lifecourse Exposure-To-Health-Effects Model (PLETHEM) is a modeling platformed developed by us with funding from the American Chemistry Council and under a Memorandum of Understanding with EPA-NCCT.
PLETHEM is now available as an open source R package
We are also developing a commercial version, PLETHEM PRO, which is designed for high throughput and complex modeling applications.
Contact us for more information on PLETHEM PRO
User interfaces for doing PBPK models allows the user to define Exposure, Chemical, Physiological and Metabolism datasets. These datasets form the building blocks for simulations. All the datasets and the simulations created from them are stored as a file that can be loaded on PLETHEM installed on any other machine. Similar set of interfaces also allow users to incorporate population level variability in the models.