Metabolism and Pharmacokinetics

Metabolism and Pharmacokinetics

With decades of experience in ADME, PBPK and biokinetic modeling, ScitoVation uses a statistically rigorous basis for addressing population variability and combining data/parameter estimates from diverse sources. Senior fellows, Dr. Mel Andersen and Dr. Harvey Clewell, were key members of the brain trust that founded and first implemented PBPK modeling in risk assessment. This work has resulted in over 100 publications, several book chapters and an annual one-week course on PBPK and its applications hosted by ScitoVation.

ScitoVation staff are also experienced with Bayesian inference and Markov chain Monte Carlo modeling to determine model parameters, especially in the context of PBPK models. Across a constantly changing landscape, our solutions bridge gaps — offering structure, while promoting scientific advancement and creativity.

Our Expertise

  • PBPK modeling
  • IVIVE
  • Pharmacokinetic Modeling
  • Invitro metabolism/PK studies